In view of the problem of guizhou “Uncaria rhynchophylla” wild resources reducing,and the low yield and the poor quality,it was studied by screening biological organic fertilizer and improving the soil fertility of Uncaria rhynchophylla regions to improve the yield and quality.The results showed that the yield and quality of Uncaria rhynchophylla were improved,and the soil fertility was enriched by organic fertilizer.The gzIV organic fertilizer was the best on improving agronomic traits,yield of Uncaria rhynchophylla and enriching the soil fertility.However,the gzIII organic fertilizer was the best on improving the quality of Uncaria rhynchophylla and soil microecological structure.