In order to study the contents variety of the mineral elements N,P,K,Ca,Mg,B,Cu,Fe,Mn and Zn in fluecured tobacco leaves and their correlation with dry matter accumulation under different fertilization patterns,the main fluecured tobacco variety grown in Nanyang,Yunya 87,had been used as the test material for comparison test in 2015~2016.Three treatments were set up,ieT1:conventional irrigation and fertilization,T2：water and fertilizer integration,T3：water and fertilizer integration+biopotassium fertilizer.The results showed that the contents of the 10 kinds of mineral elements in the tobacco were in the order of N> Ca> K> P>Mg > Mn> Fe> Zn> B> Cu,and they were higher in treatments of T2 and T3 than T1.The annual variation trend of mineral elements in leaves under different fertilization patterns showed as that N,Ca,Mn and Zn had a tendency to rise firstly and then decreased and reached the peak at 60~80 d,K,Cu and Fe decreased continuously,Mg decreased firstly and then rised,the changes of B and P content in the whole growth period were not obvious.There were significant positive correlations between the content of N,P and K in leaves,indicating that there were synergistic effects among N,P and K.There was a significant negative correlation between the change of Fe and N,Ca,Mg,Mn contents,indicating that there was antagonistic effect between Fe and N,Ca,Mg,Mn.The correlation analysis between elemental contents and dry matter accumulation showed that N,P and K had significant positive correlation with dry matter accumulation in 40~70 days.In summary,the water and fertilizer integration can improve the absorption and accumulation of mineral elements,promote the maturity and yellowing at the later stage,and increase the dry matter accumulation.