This study was conducted to evaluate the effect of the combination biogas residue with chemical fertilizer on the maize growth and physicochemical properties of soil with five treatments(CK,100%HF,40%ZF+60%HF,60%ZF+40%HF and 80%ZF+20%HF),based on the condition of equal nitrogen fertilization.The results showed that the combination biogas residue with chemical fertilizer increased organic matter concentration and the positive correlation was found between biogas residue amounts and organic matter concentration.In comparison to 100%HF treatment,the combination biogas residue and chemical fertilizer decreased available nutrient contents of nitrogen,phosphorus,potassium in soil and leaf chlorophyll content at seedling stage(0520),shooting stage(0605)and heading stage(06-28),but increased them at maturing stage(07-20).The combination biogas residue with chemical fertilizer at different levels promoted the increase of the soil pH and it was found that the treatment of 80%ZF+20%HF was beneficial for pH increase.Maize yield was the highest with 40%ZF+60%HF,yet no differences were seen between 40%ZF+60%HF and 60%ZF+40%HF.The maize quality was improved including the increase in crude protein,crude fat and crude starch as biogas residue and chemical fertilizer were jointly applied into soil.The data also indicated that the combination 80% biogas residue with 20% chemical fertilizer waste was the best for maize quality.Therefore,it was concluded that the substitution of 40% chemical fertilizer with biogas residue was a reasonable proportion for maize growth.