In order to study the effect of application of organic fertilizer drip irrigation on the quality of wine grapes andwine， field experiment was conducted using 5-year-old wine grape“Cabernet Sauvignon”as thematerial.Five treatments wassetup，including the conventional fertilization(CK)，conventional fertilization + bio -organic fertilizer extract(T1)，conventional fertilization + amino acid fertilizer(T2)，conventional fertilization + seaweed fertilizer(T3)，conventionalfertilization + biogas slurry fertilizer(T4)，and the quality of wine grapes and wines under different organic drip irrigationtreatments wasanalyzed.Through principal component and clusteringanalysis，the quality difference under differentfertilization treatments was comprehensivelyevaluated，and the shortest distance method was used to systematicallycluster each fertilization treatment.There was a significant or extremely significant positive correlation between the qualityindexes of wine grapes and wines.The overall quality ranking was T3>T4>T2>T1>CK.The quality of grapes and winesunder different fertilization treatments could be clustered into three categories.Conventional fertilization treatment wasclustered into the first clustering，and the quality was third -class.The conventional fertilization + bio -organic fertilizerextract，and conventional treatment + amino acid were clustered into the second clustering，the quality was second -class.Conventional fertilization + seaweed fertilizer and conventional fertilization + biogas slurry fertilizer were clustered intothe third clustering，and the quality was thebest.By comprehensive evaluation，T3 was the most effective in improving thequality of grapes andwine.