In order to obtain the best fertilization scheme for the large-scale production of Crocus sativus L. bulbs，Crocus sativus L. bulbs were used as materials and 7 fertilization treatments were conducted to investigate the effects of fertilization on the growth dynamics，quality and yield of new-born bulbs. The result showed that the cue ball was the “nutrient source” of the new-born bulbs，and gradually replaced by root system to transport nutrients. At returning green stage，nitrogen significantly promoted the weight，enhanced photosynthesis and protein synthesis of new-born bulbs，phosphorus and microelement fertilizers improved soluble sugar and starch accumulation. Sheep manure showed the best ability for nutrient supply in the periods of rapid growth and maturity，and the demand of phosphorus and potassium were also higher. It is recommended that sheep manure can be used as base fertilizer，nitrogen should be applied by top-dressing during returning green stage，and phosphorus and potassium can be applied in the period of rapid growth and maturity，and micro-fertilizer can be appropriately added in the top-dressing process.