To provide the theoretical basis of fertilization for high quality and yield of Carya cathayensis in Karst area of Guangxi，fertilization experiment was carried out in Huanjiang County，Guangxi. Six treatments were set up，including CK(conventional fertilization)，T1(80% conventional fertilization，urea and potassium dihydrogen phosphate foliar fertilizer)，T2(T1 and micro element foliar fertilizer)，T3(T2 and aminoacid foliar fertilizer)，T4(T2 and humic acid foliar fertilizer)，T5(T2 combined with aminoacid foliar fertilizer and humic acid foliar fertilizer). The yield，quality，mineral contents and leaf nitrogen，phosphorus and potassium nutrient of Carya cathayensis were analyzed. Results showed that，different fertilization treatments significantly affected the single weight，kernel percentage and nutshell thickness(P<0.05). The yield per plant，single weight of kernel，and kernel percentage of T4 treatment were the highest in all treatments，which was 31.18%，17.29% and 13.95% higher than those of the control treatment，respectively. The soluble sugar content，tannin content and fat content were significantly affected by different treatments(P<0.05). The contents of proteinm，starch and fat of Carya cathayensis in T5 treatment were the highest，which were 16.24%，6.43% and 13.73% higher than those in CK treatment，respectively. The mineral contents of Carya cathayensis were obviously improved by spraying foliar fertilizer. Except for the calcium content of T3 treatment，the mineral contents for foliar fertilizer spraying treatments were higher than that of CK treatment. The magnesium，zinc，iron，boron and calcium of Carya cathayensis in T5 treatment were the highest among all treatments，which were 9.87%，39.34%，35.44%，18.10% and 10.93% higher than those in CK treatment，respectively. In conclusion，the yield of Carya cathayensis in T4 treatment was the highest among all treatments，and T5 treatment was the best way to improve the quality and mineral contents of Carya cathayensis. Therefore，the corresponding foliar fertilizer spraying scheme can be selected according to the demand for Carya cathayensis.