Straw is difficult to degrade under natural conditions，which is not conducive to ecological protection and sustainable development. In the preliminary research，the use of Trichoderma asperellum microbial inoculum to degrade corn straw was prepared. Although it has good cellulose degradation ability，its degradation rate needs to be improved. A study was conducted to enhance the degradation of corn stover by using an activated nutrient package to enhance the degradation rate and further optimize the degradation plan. Through a single factor experiment，four different quick acting carbon sources，four quick acting nitrogen sources，and five inorganic salts were prepared into nutrient solutions，which were then combined with the wettable powder of Trichoderma asperellum. The degradation rate of straw was measured at different time stages to determine the composition and proportion of different nutrients in the nutrient package formula. On the basis of single factor screening，appropriate concentrations of variables were selected to design a response surface experiment with three factors and three levels for sucrose，ammonium sulfate，and zinc sulfate. Design Expert. 8 was used to analyze the experimental data，determine and validate the theoretical optimal group formula. The activated nutrition package of Aspergillus oxysporum was prepared according to the mass ratio. Through single factor experiments，the optimal formula for activating nutrient packs with 1‰ sucrose，1‰ ammonium sulfate and 0.5‰ zinc sulfate was determined. After 15 days of cultivation，the degradation rates of corn straw reached(39.63±2.01)%，(35.67±1.46)% and(39.66±0.85)%，respectively；Through response surface optimization，the theoretical optimal group was determined to be 1.02‰ sucrose，1.05‰ ammonium sulfate and 0.35‰ zinc sulfate. Validation experiments were conducted on them，and after 15 days，the degradation rate of corn straw was(41.32±0.57)%，which was very close to the predicted value. Finally，sucrose，ammonium sulfate，and zinc sulfate were used in a 20∶21∶7 ratio to prepare a bacterial activation nutrient package. According to the optimal composition and proportion，a microbial activation nutrient package was prepared. When used together with the microbial agent，it could significantly improve the degradation effect of corn straw，increase the straw return rate，enhance soil fertility，and further optimize the technical scheme.