Fertilizer was not used in some mulberry field, or used rarely in others in Hechi region, Guangxi Chuang municipality, that induced leaf yield decreasing and soil cultivation characters deterioration. By analyzing the experiment results of fertilizer balance technology application for three years, show that special fertilizer which the ratio of N,P_2O_5, K_2O equal to2:1:2 and contain 20 percent organic matter was the best in all experiment, comparing with the contrast, it can increase the leaf yield 47.4 percent and 7315.2 RMB per hectare.