The effects of soil compaction stress on growth of Scutellaria baicalensis are studied in this paper in order to provide scientific base for improving the quantity and quality of Scutellaria baicalensis.A pot experiment was carried out to study effects of soil compaction on growth，quantity and quality of Scutellaria baicalensis by simulating three soil bulk densities which are 1.20，1.35 and 1.50 g/cm3 respectively.The results showed that the plant height，stem diameter，root rhizome，root length，shoot mass and root mass will decrease with the increasing of soil bulk density.Compared with soil bulk density of 120 g/cm3，the aboveground mass of scutellariae decreased by 5.88% and 22.35% respectively for the treatments of 1.35 g/cm3 and 1.50 g/cm3 soil bulk density，the root mass of Scutellariae baicalensis decreased 10.72% and 18.76% respectively，and there is a significant difference between the 1.35 g/cm3 and 1.50 g/cm3 soil bulk density.Bicalin content in treatments of 1.35 g/cm3 and 1.50 g/cm3 reduced by 23.95%，52.75% respectively for the treatment of 1.20 g/cm3,and the difference between 1.35 g/cm3 and 1.50 g/cm3 soil bulk density processing is significantly.The results also showed that with the increasing of soil bulk density，the root activity，soluble protein，chlorophyll content decreased，the malondialdehyde (MDA) content and the activities of superoxide dismutase (SOD)，peroxidase (POD) and catalase (CAT) increased.Under the condition of this experiment，1.20 g/cm3 soil bulk density is best to the growth of the plant，and the output and content of effective elements.