The effect of different fertigation methods on growth,nutrient uptake,and yield of cotton were investigated through a field experiment with the equal fertilization rate and the equal cost.Four fertigation methods were set as conventional fertilizer basal application (CK),conventional fertilizer topdressing (DCK),ordinary drip irrigation with specific fertilizer (F1),and high phosphorus and potassium fertilizer for drip irrigation (F2).Results showed that under the equal fertilization rate conditions,the dry weight,nutrient uptake,and yield of cotton in F1 and F2 treatments were significantly higher than CK,but there was no significant difference between F1 and DCK treatments.CK treatment had the least N and P use efficiency,and no significant difference was found between F1 and DCK treatments.The highest N and P use efficiency was found in F2 treatment.Under the equal fertilization cost conditions,treatment of DCK had the highest dry weight,nutrient uptake,and yield of cotton.There were no significant differences among CK,F1,and F2 treatments.Therefore,the special fertilizer for drip irrigation had better application effect on cotton yield and nutrient uptake,especially for high phosphorus and potassium fertilizer.But how to reduce the cost of fertilizer is an important problem faced by special fertilizer for drip irrigation.