In order to explore the rational application of potassium and phosphorous fertilizers in tobacco cultivations in the red soil of Jiangxi province,a field trial was conducted to study the effects of potassium and phosphorous fertilizers mixed application on yield,quality and nutrient distribution of fluecured tobacco planted in red soil using the tobacco variety“K326”as the tested materials.The results showed that tobacco plant growing was poor and economic benefit of fluecured tobacco was low without the application of potassium and phosphorous fertilizers,but tobacco plant growing was well in case of potassium and phosphorous fertilizers mixed application.High levels of phosphorus and potassium fertilizers mixed application could improve the quality and economic efficiency of fluecured tobacco.The total sugar,reducing sugar and the rate of sugar to nicotine was increased and nicotine and total N was decreased with the increasing of phosphorus and potassium fertilizers mixed application.Born content of tobacco was positively correlated to the content of nicotine or total N,but negatively correlated to the content of total sugar or reducing sugar,and tobacco iron content was significantly negative correlated to nicotine.So it is suggested that the application of N 142.5 kg/hm2 with N∶P2O5∶K2O =1∶1.2∶3.0 was recommended for the balance of nicotine and improving the quality of fluecured tobacco in the tobaccogrowing areas of red soil in Jiangxi province.