Field experiment was conducted to study the effects of organicinorganic special compound fertilizer (OISCF) on fruit yield，quality，and nutrient uptake of grape.Four treatments were set: CK (no fertilizer)，XG (traditional fertilization)，DL (equal total of N，P2O5，K2O amount of OISCF was used instead of normal fertilizers) and TJ (recommend amount of OISCF).The results showed that the grape yield of TJ was increased by 25.8% and 5.1% comparing with CK and XG respectively.Compared to CK，XG and DL treatments，the TJ grape fruits titratable acid decreased significantly by 10.7%~42.9%，total soluble solid increased by 1.8%~8.2%，Vitamin C increased by 6.4%~77.7%，and TA/TSS increased by 10.2%~60.4%.However，the total amount of N，P2O5 and K2O fertilization of TJ treatment was 42.5% less than the treatments of XG and DL，while grape leaf Fe，Cu contents and fruit Fe absorption were increased significantly by organicinorganic special compound fertilizer.In conclusion，recommended fertilization of OISCF kept grape fruit yield and improved fruit quality but declined the N，P2O5 and K2O application rate considerably.