The effects of mesoporous silica nanoparticles（MSN）on the Cd accumulation in rice were investigated by pot experiments.The results showed that MSN significantly increased the pH of soil solution and inhibited Cd bioavailability.Soil available Cd concentration in soil decreased by 63.07%，81.30% and 93.02% under the 0.5%，1.0% and 2.0% MSN treatments，respectively.MSN significantly reduced the Cd content in rice grain.The Cd content of fresh rice sample decreased from 0.363 mg/kg to 0.045 5 mg/kg，0.032 5 mg/kg and 0.020 7 mg/kg under the 0.5%，1.0% and 2.0% MSN treatments，respectively.The Cd content in all rice grain met the edible standards.It was concluded that MSN could be used to restore Cd contaminated soil.