A field experiment was carried out to explore the effect of ratios ofnitrogen(N)andpotassium(K)applicationon yield and nutrient absorption ofpotato，and to provide a basis for scientific recommendation of fertilization for high yieldpotato in alpine area of Guizhou province. Different amounts of N and K treatments with same amount ofphosphorus(P)were conducted in 2018 in Bijie city，Guizhou province.Yield，economic benefit，nutrient uptake and utilization of potatowere determined and analyzed. Potato yield varied with different nutrienttreatments，theyield，output value and economicbenefit ofT8(N 3P2K2，N∶P 2O5∶K2O=270∶150∶240 kg/hm²)were 30 145 kg/hm²，33 159.5 yuan/hm² and 29 823.5 yuan/hm²，respectively，which were higher than other treatments by 1 294～ 12 967 kg/hm²，1 423.3～ 14 263.2 yuan/hm² and 2 068.3～ 10 927.2 yuan/hm². The biomass of potato tubers under different treatments showed an increasingtrend，and T8treatment was the largest. Similar to abovegroundbiomass，the total biomass increased firstly and thendecreased，reachingthe maximum at 117 days after planting，and total biomass of T8 treatment was 6 619 kg/hm²，which was higher than that of other treatments. The change of potato nutrient accumulation was different in different parts of the same treatment. The change of potato nutrient accumulation was similar in different parts of the same treatment.The change trend of potato Nand K accumulation in the same part was similar，the accumulation of N and K in the above -ground part increased firstly and then decreased slowly. The accumulation of N and K in potato tubers continued to increase. The total accumulation ofN and K was similar to that of the aboveground nutrients，showing a trend of first increasing and then slowly decreasing.N and K nutrient use efficiency was different in different treatments. T4(N 1P2K2，N∶P 2O5 ∶K2O=90 ∶ 150 ∶ 240 kg/hm²)andT8(N 3P2K2，N∶P 2O5∶K2O=270∶150∶240 kg/hm²)had the largest PEP N and AEN，whileT5(N 2P2K1， N∶P2O5∶K2O=180∶150∶120 kg/hm²)andT7(N 2P2K3，N∶P 2O5∶K2O=180∶150∶360 kg/hm²)had the largest PEP K and AEK. Comprehensive considering theyield，economic benefit and nutrient uptake andutilization，T8 treatment(N3P2K2， N∶P2O5∶K2O=270∶150∶240 kg/hm²)can be used as a suitable ratios of N and K under the conditions of this experiment. And we should pay attention to the rational operation of N and K in production to promote the sustainable development in potato industry.