The main producing area of adzuki bean is in northeast and north of China. The low yield of adzuki bean is causedby unbalancenitrogen，phosphorus and potassium fertilization. In order to explore the needs and the best fertilization of thethree elements，quadratic orthogonal regressive rotation design of three factors was applied to study the effects of fertilizerson the yield. The results showed that the yield was increased by adjusting proportioning and dosage of fertilizers，when N∶P2O5∶K2O＝ 1∶0.55∶0.98(N:76.6 kg/hm²)，the maximum yield was 2 096.7 kg/hm²；when N∶P 2O5∶K2O＝1∶0.53∶0.86(N:64.3 kg/hm²)，the best economic benefit was 12 432.73 yuan/hm². The interaction effect of the three elements on the yield showed that it increased to the peak gradually then decreased gradually by increasing N and P or P andKfertilization，and it increased gradually then decreased rapidly by increasing P and K fertilization. Pods per plant of adzukibean rose then fell with increasing N or Kfertilization，and it kept on increasing with P fertilization increased in the range ofthe experiment. The three elements had little effect on seeds of per pod of adzukibean，which proved that was self -determined by the cultivar. 100-seed weight increased with increasing theN，P and K fertilization.