This paper aim to explore the effects of foliar and soil application of selenium on the contents ofselenium，mineral elements and the fruit quality of Mangifera indica L.，which will provide the theoretical basis and technology support for the safety production of selenium-rich mango. Mango cultivar“Guire 82”was used as the experimentalmaterial，and the sodiumselenite solution was selected as selenium source in spraying selenium experiment，and six concentrations were designed，including0.0，25.0，50.0，100.0，150.0 and 200.0 mg/L. The solution of treatments was sprayed twice every 15 days after physiological fruit drop time. The soil selenium experiment included 10 g/plant sodium selenite and 10 g/plant sodium selenate treatment at flowering. The results indicated that selenium both in leaves and fruits increased in response to the increasing selenium concentration after spraying different concentrations of sodium selenite on the leaves of Mangifera indica L. Bothselenite and selenate soil selenium treatments increased the selenium content in leaves andfruits，while selenate treatmentwas more effective. Spraying 50 mg/L sodium selenite significantly increased the content of Vc infruit，and 200 mg/L sodiumselenite significantly increased the content of K and titration acid in fruit，while spraying 100～ 200 mg/L sodium selenite significantly decreased Zn and Ca content in fruit. The soil treatment with 10 g/plant sodium selenite significantly decreased Caand Mg content infruit，while the selenate treatment at the same dose significantly increased K and Vc content and decreasedCa content in fruit. Both foliar and soil application of selenium increased the contents of selenium in leaves andfruits，where foliar application increased much more than soil application. Sodium selenate was easier to be absorbed than sodium selenite in soil selenium application. Spraying 25.0～ 50.0 mg/L sodium selenite or soil treatment with 10 g/plant sodium selenate could be recommended for the production of Se-enriched mango.