Pot experiment was conducted to study the effects of Bacillussp.KTS-1-1 and/or NPK compound fertilizer on the growth and metabolism of Pseudostellaria heterophylla，and seven treatments were set up asfollows:T1:KTS -1-1+0.25g NPK compound fertilizer(100 mL 3×10 8CFU·mL -1 cell suspension +100 mL solution containing 0.25 g of compound fertilizer)；T2:KTS -1-1+0.5 g NPK compound fertilizer(100 mL 3×10 8CFU·mL -1 cell suspension +100 mL solutioncontaining 0.5 g of compound fertilizer)；T3:KTS -1-1+1.0 g NPK compound fertilizer(100 mL 3×10 8CFU·mL -1 cellsuspension +100 mL solution containing 1.0 g of compound fertilizer)；T4:2 g compound fertilizer(200 mL solutioncontaining 2.0 g of compound fertilizer)；T5:Spraying KTS -1-1 alone(200 mL 3×10 8CFU·mL -1cell suspension)；T6:Soakingseeds(200 mL 3×10 8CFU·mL -1cellsuspension)；T7:Control(200 mL tapwater).Pseudostellaria heterophylla was sprayed as the above-mentioned seven treatments after flowering，and sampled to measure the items related to thegrowth and metabolism a monthlater.The results showedthat，in comparison with T4 andT7，the combined application of growth-promoting rhizobacteria Bacillus sp. KTS-1-1 and NPK compound fertilizer increased the biomass of Pseudostellaria heterophylla，and the combined application of growth -promoting rhizobacteria Bacillus sp. KTS-1-1 and low or medium doseof NPK compoundfertilizer(T1，T2)would be beneficial to the improvements of the carbon metabolites -reducing sugar andchlorophyll，nitrogen metabolites -ammoniumnitrogen，totalproteins，total amino acid and nitrate reductase and the indexes of adverse circumstances-resistance viz.peroxidase，catalase，ascorbate peroxidase，phenylalanine ammonialyase，malondialdehyde，total phenolics andlignin，and decrease the contents of abscisic acid inleaves.Therefore，the schemes of the combined application of growth-promoting rhizobacteria Bacillus sp. KTS-1-1 and reduction of 75.0%～ 87.5% of NPK compound fertilizer were adopted to promote the plant growth and the accumulation of carbon and nitrogen metabolites in Pseudostellaria heterophylla and improve the resistance towards the adverse circumstances in the fields.