By studying the effects of different chemical fertilizer reductions combined with organic liquid fertilizers on the growth of processed tomatoes and soil enzyme activity，it provides theoretical basis and technical support for the feasibility of chemical fertilizers reduction combined with organic liquid fertilizers and reducing fertilizer application and increasing effect in crop cultivation.Using micro-area control test，five treatments were set up，blank control (NF)，single application of chemical fertilizer (CF100)，full application of chemical fertilizer with organic liquid fertilizer(CF100SW)，chemical fertilizer reduction of 10% with organic liquid fertilizer (CF90SW)，and chemical fertilizer reduction of 20% with organic liquid fertilizer (CF80SW). The effects of these treatments on nutrient absorption，yield，quality of tomato and soil enzyme activity were analyzed.The results showed that the CF100SW，CF90SW，and CF80SW treatments significantly enhanced the absorption of nitrogen and phosphorus nutrients and the utilization of nitrogen and phosphorus fertilizers compared with the CF100 treatment.Among them，CF80SW treatment was more effective，the absorption increased by 25.15%，11.59%，and nitrogen and phosphate utilization rates reached 34.00% and 15.89% respectively，compared with the CF100 treatment.Compared with the chemical fertilizer application alone，the yield of CF100SW treatment was the highest，which increased 12.34%，followed by CF90SW treatment，which increased by 4.23%；Organic liquid fertilizer treatments (CF100SW，CF90SW，CF80SW) increased the content of tomato vitamin C and lycopene，significantly increased the activities of soil protease，invertase，cellulase，alkaline phosphatase，β-glucosidase，in which the activities of soil cellulase and invertase increased most significantly.CF100SW，CF90SW and CF80SW treatments had 35.59%，43.64% and 29.98% higher cellulase activity than those treated with CF100；invertase activity increased 28.68%，58.44%，45.49%.To sum up，the application of organic liquid fertilizer can promote nutrient absorption of processed tomatoes，increase fertilizer utilization rate，increase yield and quality，and create a good soil micro-environment；and from the comprehensive perspective of yield，nutrient absorption，and fertilizer utilization rate，an appropriate reduction of 10%～20% of chemical fertilizers are more suitable with organic liquid fertilizers.