Excessive application of chemical fertilizers is a big problem in the maize planting for seed production in Hexi oasis irrigated area.In order to explore an efficient path to fertilizer reduction，three field experiments were conducted in Zhangye，Gansu，including the chemical fertilizer combined with organic fertilizer，the chemical fertilizer combined with medium and trace element and maize for seed production intercropping with green manure.The yields of maize of the experiments were analyzed to explore effective measures to reduce the application of fertilizer.The results showed that in present study，the appropriate application rate of fertilizer for maize for seed production was N 300 kg·hm-2，P2O5 150 kg·hm-2 and K2O 150 kg·hm-2，respectively.Compared to the fertilizer treatment，the yield of the fertilizer combined with organic fertilizer treatments increased by 14% averagely.Compared with N450P150K150，the nitrogen rate was reduced by 33.3% for MN300P150K150，however，the yield of maize for seed production increased by 9.7%.In the experiment of the fertilizer combined with medium and trace element，compared to N375P150K150，the yield of maize for seed production for N375P150K150S increased by 14%，and compared with N450P150K150，nitrogen rate decreased by 16.6%，but yield of maize for seed production increased by 10.4%.In the experiment maize for seed production intercropping with green manure，compared to cutting and stay stubble + N388.5，the reduction rates of nitrogen for all green manure turnover + N358.5 and all green manure turnover + N313.5 were 10% and 25%，respectively，nevertheless，the yield of maize for seed production increased by 0.5% and 2.2%，respectively.To sum up，it is an effective way of reduction fertilizer for maize for seed production to apply organic fertilizer，medium and trace elements，and intercropping green manure，and combination with N 300 kg·hm-2 is appropriate to maize for seed production in Hexi oasis irrigated area.