Aiming at the potential pollution risk of urban domestic sludge applied to farmland， field experiment was carried out to explore the impacts of the application of urban domestic sludge on the yield， quality and safety of wheat， in order to provide a basis for the utilization of urban domestic sludge in agriculture.The results showed that the application of municipal sewage sludge improved wheat yield.The yield of wheat under single application of domestic sludge (T2， T3) was increased by 83.85%～139.04% compared with that of CK treatment.Within a certain range， the wheat yield increased with the increase of the amount of domestic sludge.The treatment of domestic sludge 2250 kg/hm² with compound fertilizer 450 kg/hm²(T6) was more conducive to the increase of wheat yield， and the rational application of urban domestic sludge was conducive to the replacement of organic nutrients and the reduction of fertilizer.The application of municipal sewage sludge was beneficial to the improvement of wheat grain quality.Compared with CK treatment， the contents of wheat grain dry gluten， wet gluten and starch were significantly increased by applying domestic sludge， and the contents of wheat grain dry gluten and wet gluten were increased by 19.7%， 15.2% and 7.83% by applying domestic sludge alone at 6000 kg/hm²(T3) .The Cr content in wheat grains of some fertilizers treated with domestic sludge (T4， T9) exceeded the national limit(1 mg/kg).With the increase of domestic sludge， the risk of heavy metal enrichment in wheat grains increased， but the increase of different elements was different.The contents of polycyclic aromatic hydrocarbons and phthalates organic pollutants in wheat seeds were in line with the national food safety standards.For agricultural use of urban domestic sludge， it is recommended to apply it separately at the level of 6000 kg/hm².In the case of the combination application of domestic sludge and chemical fertilizer， 2250 kg/hm² of domestic sludge + compound fertilizer(15-15-15) 450 kg/hm² of dosage is recommended.