In this study， the long-term site-specific test was carried out from 2016 to 2019 to monitor the yield， quality and soil nutrients of different base fertilizer dosage， so as to provide data support for scientific fertilization of lettuce. Four base fertilizer levels， including CK( 0 kg/hm²)， 1/2CG( 375 kg/hm²)， 3/4CG( 562.5 kg/hm²) and farmers’ habits CG( 750 kg/hm²)were set up， to determine the yield， quality and soil nutrients of eight crops of lettuce for 4 consecutive years. The results showed that the yield of lettuce treated by CK was significantly lower than that of other treatments from the 2 nd crop. The average yield of lettuce treated by 1/2CG was the highest. Spring and autumn crops were 15.17% and 10.06% higher than CK treatment. Compared with CG treatment， the yield of lettuce treated were 3.95% and 3.24% higher. The increase of application amount of base fertilizer formula significantly improve the yield of lettuce. And the appropriate reduction of the amount of base fertilizer formula did not reduce the yield of lettuce. The nitrate content of lettuce treated with 1/2CG was significantly lower than that of CG treatment. The contents of Vc treated with 1/2CG and 3/4CG increased compared with that treated with CG. Appropriate reduction of base fertilizer formula could increase the content of Vc and reduce the content of nitrate in lettuce. It could increase the content of available nutrients in soil and play an important role in maintaining available phosphorus and available potassium in soil. Based on the fitting equation of application amount and yields of base fertilizer formula， under the condition of N-P2O5-K2O( 18-9-18)， the recommended amount of base fertilizer formula for lettuce spring crop is 478.64 kg/hm²， and 453.75 kg/hm² for autumn crop.