Huanjiang County is the main grain production area in Guangxi. Heavy metal pollution in this area is serious，but there is a lack of domestic remediation technology for heavy metal compound pollution. In order to reduce the content of heavy metals in crops planted in the compound contaminated soil， more and more people are beginning to study the effects of different planting models on the absorption of heavy metals in crops. Intercropping mode can regulate the use of nutrients in the field， reduce the plant’s absorption of heavy metals and it is effective for soil remediation and product improvement. Therefore， this study took the polluted farmland in the mining area as the background. The tested soil was the soil contaminated by the collapse of the tailings dam of the lead-zinc pyrite mine， and the intercropping mode included centipede grass-corn， centipede grass-soybean， soybean-corn， sugarcane-soybean. A randomized block design was adopted and the experiment period was 1 year. The contents of heavy metals were determined by atomic absorption spectrometry and graphite furnace atomic absorption spectrometry. By comparing and analyzing the contents of Zn， As， Cd and Pb in each part of single and intercropping crops， the effects of intercropping modes on the accumulation of heavy metals in crops and crop safety were explored. The results showed that the change of crop heavy metal content was significantly affected by intercropping. The Pb content in corn-soybean intercropping mode was 38% lower than that of single corn. At the same time， the data showed that different parts of the crop had different enrichment capacities for heavy metals. The distribution of As in soybeans was leaf>stem>root，but the Pb was root>leaf>stem. In summary， in compound contaminated soil， intercropping can significantly decrease the pollution of heavy metals to plants. These results confirm that intercropping is a possible resolution for the remediation of heavy metal soils. However， planting food crops in the experimental area poses a greater health risk， and the contaminated soil needs further control.