Aiming at the problems in the terroir characteristics of Ningxia Helan Mountain wine producing area，such as the lack of distinct characteristics，flavor and aroma due to the poor availability of mineral nutrients，etc.，taking 6-year-old “Cabernet Sauvignon” as the object of study，5 different levels of calcium gluconate spraying were set up: 1.2 L·hm-2 (T1)，2.4 L·hm-2(T2)，3.6 L·hm-2(T3)，4.8 L·hm-2(T4)and 6.0 L·hm-2(T5)，and water spraying was used as the control group(CK)to study the effects of foliar calcium gluconate spraying on the quality and yield of wine grapes. Results showed that comparing with CK，the spike length，hundred grain weight，yield，tannin，total phenol and input-output ratio of foliar calcium gluconate spraying treatment increased significantly and T2 treatment was the highest，the ear length，hundred grain weight，yield，tannin and total phenol，input-output ratio of T2 treatment，compared with other spraying calcium gluconate treatment，increased by 3.96%～17.49%，9.54%～16.62%，5.48%～23.59%，8.96%～21.12%，4.51%～13.54% and 6.98%～20.00%，respectively. The indexes of transverse diameter，longitudinal diameter and fruit type were the highest in T3 treatment，which increased by 1.71%～10.50%，5.33%～23.64% and 3.92%～7.07 %，respectively，compared with other treatments. The soluble solids and anthocyanins were the highest in T4 treatment，with an increase of 5.86% and 43.24%，respectively，compared with CK treatment，and an increase of 2.07%～5.58 % and 15.22%～29.27 %，respectively，compared with other treatments. The titrable acid was the lowest in T2 treatment，and the decrease range of leaves sprayed with calcium gluconate was 6.49%～28.33% compared with CK treatment. In short，in the wine producing areas at the eastern foot of Helan Mountain，the leaves were sprayed with calcium gluconate could effectively promote the improvement of grape berry quality，and the optimal effect was achieved when the amount of calcium gluconate sprayed on the foliar was controlled at about 2.4 L·hm-2.