A pot experiment was carried out to study the effects of using municipal solid waste compost(MSWC)together with non-native plant Dactylis glomerata L.(D. glomerata)and native plant Erica australis L.(E. australis)on vegetation restoration and soil enzymatic activities of the topsoil of S.Domingos’ mine tailing in Portugal. The results showed that as compared to the soils without MSWC，using MSWC not only significantly increased soil pH and the concentration of water-soluble minerals(P，As，Fe，K，Ca，Mg，Na)，but also the growth of D. glomerata and E. australis were stimulated apparently by 0.69～0.91 and 7.75～8.83 times higher than that of without MSWC，and the increased rate of E. australis was highest with the amount of 15 g/kg of MSWC. Meanwhile，enzymatic activities of all tested soil were enhanced greatly by using MSWC. Two kinds of plant species showed different effects on the soil enzymatic activities. As compared to the soil with E. australis，the presence of D. glomerata in the amended soils with MSWC led to the greatest activities of soil dehydrogenase，β-glucosidase，acid phosphatase and cellulase with the increases of 176.08%～379.16%，186.53%～294.23%，195.27%～204.76% and 395.64%～552.04%，respectively. Although the growth of E. australis increased the activities of protease significantly compared to the soil without plant，the activities of dehydrogenase，β-glucosidase，acid phosphatase were restrained. This negative impact might be attributed to the root exudates such as phenolic compounds. In conclusion，MSWC should be a good material to restore the vegetation cover for the topsoil in this mine tailing due to its significant improvement in soil chemical parameters，plant growth and soil enzymatic activities and little effect on the availability of heavy metals in the topsoil. D. glomerata could maintain permanent grassland but needed a regular input of mineral fertilizers and thus caused higher cost. In spite of slow growing and lower biomass，and as a kind of plant grown with little nutrients requirement，which was more suitable for the harsh environment of mine tailing and thus resulted in less cost，E. australis represented a competitive advantages over D. glomerata on the restoration of the topsoil in this mine tailing.