In order to study the key parameters of nutrient management in flue-cured tobacco-growing regions of Mianning county，Liangshan district，a field experiment was conducted to explore the influence of different nitrogen，phosphorus and potassium rates on yield，characteristics of nutrient absorption and utilization and fertilizer functions using the tobacco cultivar Yunyan87.The results showed that the effects of nitrogen，phosphorus and potassium on flue-cured tobacco yield in Liangshan tobacco growing area were as follows: nitrogen>phosphorus>potassium.Treatment VI(N 90 kg/hm²，P2O5 90 kg/hm²，K2O 270 kg/hm²)achieved the highest yield which was 3107.2 kg/hm² among all the 9 treatments，and it had the best nitrogen，phosphorus and potassium fertilizer utilization rates which were 31.1%，3.2% and 15.2%，agronomic utilization rates of nitrogen，phosphorus and potassium were 9.17，7.48，1.91 kg/kg，and the partial productivity of nitrogen，phosphorus and potassium were 34.52，34.52，11.51 kg/kg，respectively.The yield to nitrogen and phosphorus fertilizer application was simulated by the binary quadratic fertilizer response function which was y=1584.273+19.44N+14.162P-0.007NP-0.115N2-0.071P2(R2=0.8300).According to the yield，fertilizer use efficiency and benefit synthetically，it is suggested that the recommended application rates of nitrogen，phosphorus and potassium were 81～90，90～95，270 kg/hm²，respectively.According to the effects on nitrogen，phosphorus and potassium absorption and accumulation in tobacco plants，it is suggested that N and K fertilizer should be applied in the way of base application combined with topdressing，amd topdressing should be carried out in 6～7 weeks after transplanting.The determination of key parameters of nutrient management is helpful to guide the scientific fertilization of local flue-cured tobacco.