The purpose was to explore the effects of combined application of nitrogen，phosphorus and potassium fertilizers on the yield and quality of Fritillaria unibracteata，and to obtain a high quality and high yield nitrogen，phosphorus and potassium fertilizer application scheme. A three-factor quadratic general rotary unitized design was adopted in field fertilization test on 5 years raw F. unibracteata.After harvest，the yield，total ash，alcohol-soluble extractives，and total alkaloid content of the medicinal materials were measured.Functional equations between the yield and quality of F.unibracteata and nitrogen，phosphorus and potassium fertilization was established using the DPS.Through F-test，the significance of the regression equations and the regression coefficients was analyzed.The effects of nitrogen，phosphorus and potassium fertilizers on yield，total ash，alcohol-soluble extracts and total alkaloids were analyzed by the models.Statistical frequency method，gray correlation degree and DTOPSIS method were used to integrate various indicators to obtain the optimal fertilization plan. The application of nitrogen，phosphorus and potassium fertilizers could affect the yield and quality of F. unibracteata.In the study，the effects of various nutrient factors on the yield and total ash were:K2O>N>P2O5，and the effects on extracts and total alkaloids content were:N>P2O5>K2O.As the amount of N increased，the total ash content gradually decreased，and the total alkaloid content decreased first and then increased；as the amount of P2O5 increased，the total ash content gradually increased；as the amount of K2O increased，the total ash content increased first and then decreased.Low P2O5 and low K2O，or high P2O5 and high K2O are all conducive to the production of F. unibracteata，low N and low P2O5，or high N and high P2O5 are all conducive to increasing the extractable content of F. unibracteata.K2O has the greatest impact on yield and total ash，and N has the greatest impact on extracts and total alkaloids content.The high-quality and high-yield fertilization schemes for F.unibracteata obtained through experiments are N 163.82～190.77 kg/hm²，P2O5 541.75～720.25 kg/hm²，K2O 337.49～454.52 kg/hm².