Based on the soil samples of 0～60 cm collected at the drip head，at the edge of the mulch and at the mulched soil in three irrigated areas (Anjihai，Mosuowan and Xiayedi)of Manas River basin，the migration rules of soil moisture，salt and nutrient before and after drip irrigation and their differences were analyzed in the three irrigated areas in May，August and October 2019.The results show that:(1)The content of soil water in the three irrigated areas increased and showed consistent regularity after drip irrigation in May and August.The soil salinity in the soil profiles of the three irrigated areas was desalted from the drip head to the mulched soil in May.The salt accumulation zone of Anjihai irrigation area was formed below 30 cm at the drip head and below 10 cm at the mulched soil in August.The distribution characteristics of bidirectional desalting from the surface to the deep profile in the vertical direction and from the drip head zone to the mulched soil in the horizontal direction in Mosuowan irrigation area.The salt accumulation area of Xiayedi irrigated area was formed below 40 cm of the mulched surface.The variation of soil salinity，pH，ammonium nitrogen and nitrate nitrogen were not consistent after drip irrigation in May and August，and there were regular heterogeneity.(2)The soil salinity decreased in the order from May to October:Xiayedi>Mosuowan>Anjihai，but those seasonal differences were not significant.The soil of Anjihai irrigated area and the Xiayedi irrigated area showed salt accumulation phenomenon and the salt accumulation rates were 7.4% and 45.2%，respectively.The soil of Mosuowan irrigation area showed desalting phenomenon and the salt accumulation rate was 5.7%.The mean soil water content in Anjihai and Xiayedi irrigated areas showed a decreasing trend from May to October and the reduction rates were 9.4% and 14.5%，respectively.The soil water content in Mosuowan irrigation area showed an increasing trend and the increase rate was 12.1%.The soil pH，ammonium nitrogen and nitrate nitrogen showed obvious seasonal differences in three irrigated areas from May to October.(3)Different soil texture and groundwater depth are the main factors affecting the differences of water transport law before and after drip irrigation in the three irrigated areas. Water migration is the main factor affecting migration and distribution of salt in the three irrigated areas.Groundwater mineralization and fertilization have limited influence on the difference of salt variation among the three irrigated areas.