Due to the long-term application of chemical fertilizers，the farmland soil has various problems such as decreased fertility，acidification，compaction，excessive arsenic and cadmium content，which seriously affects the quality of farmland. Calcium-magnesium-phosphate fertilizers are alkaline and can improve acidic soil，at the same time can passivate the heavy metals in the soil，adjust the imbalance of elements，and reduce the loss of organic matter and other problems. In this experiment，the polluted farmland in Datun Town，Gejiu City，Yunnan Province was used as the background to explore the effects of applying calcium-magnesium-phosphate fertilizers on the yield of four local corn varieties(Ludan No.12，Zuyu No.7，Hongyu No.2，Huaxingdan No.88)，the content of arsenic and cadmium in the grain，and the effective arsenic，effective cadmium and pH in the soil.The main conclusions of the study are as follows:(1)Compared with bare land，Hongyu No.2 had the best soil pH improvement effect under the treatment of calcium-magnesium-phosphate fertilizer. (2)Comprehensive considering of the effect of corn varieties on the available contents of As and Cd in the soil ，Hongyu No.2 had a good effect，while Ludan No.12 had no significant effec.(3)Based on the application of calcium-magnesium-phosphate fertilizer，the yield of Hongyu No.2 reached the maximum，which indicated Hongyu No.2 was the best variety of maize for high yield.(4)Considering the effects of calcium-magnesium-phosphate fertilizers on the As and Cd content in maize kernels，Hongyu No.2 had a better effect，while Ludan No.12 was only effective in reducing As content in maize kernels.