To investigate the effect of foliar spraying of pig blood peptide and earthworm lysate on wheat yield and quality，different concentrations of foliar fertilizers，i.e.，urea，pig blood peptide and earthworm lysate，were sprayed on wheat at the nodulation，gestation and tasseling stages，and blank and water were used as controls.The results showed that porcine blood polypeptide 500 times solution significantly improved wheat yield and its composition，compared with the water control，the number of spike grains，number of spikes，thousand grain weight and actual yield increased by 11.2%，13.3%，9.9% and 11.3%，respectively.The protein and wet gluten content of pig blood polypeptide treated seeds showed an increasing trend with increasing fertilizer concentration.The number of grains per spike，number of spikes，thousand grain weight and actual yield were increased by 13.2%，9.7%，7.2% and 18.5%，respectively，the earthworm lysate diluted 2000 times compared with the water control.In the case of equal nitrogen，the yield and its constitutive factors and mineral nutrient accumulation of pig blood polypeptide 250 times solution and earthworm lysate 200 times solution treatments were lower than that of equal nitrogen urea treatment，and did not increase the yield.The protein content of porcine blood polypeptide 250 times solution and earthworm lysate 200 times solution was significantly higher than that of urea treatment by 41.6% and 11.1%，respectively.The effects of foliar spraying pig blood polypeptide and earthworm lysate on the protein content of seeds were mainly amino acid-containing functional substances rather than the effect of nitrogen alone.With a all things considered，pig blood polypeptide diluted 500 times solution had the best effect on overall optimization and improvement of wheat yield and quality；earthworm lysate 2000 times solution treatment could effectively promote the absorption of other nutrients in wheat and achieve higher yield.