In order to solve the current problem of blind fertilization in the large-scale production of Hydrangea，explore the types of high-quality fertilizer suitable for the growth and development of Hydrangea.The experiment took the H.macrophylla ‘Hanatemari’ as the test material and six fertilization treatments were set up:CK (no fertilizer)，T1 (water soluble fertilizer)，T2 (organic fertilizer)，T3 (organic fertilizer + water soluble fertilizer)，T4 (controlled-release fertilizer)，T5 (controlled-release fertilizer + water soluble fertilizer).The effects of different fertilization treatments on the growth，physiological characteristics，leaf mineral element content，soil physical and chemical properties and enzyme activities of Hydrangea were analyzed and compared.The results showed as follows:①Compared with CK，except for the intercellular carbon dioxide concentration，soil pH and electrical conductivity，the growth，physiological，photosynthetic characteristics，soil physical and chemical properties，and enzyme activity of each fertilization group showed an increasing trend；② Compared with other fertilization groups，the plant height，crown width，branch length，leaf width，stem thickness，leaf chlorophyll，carotenoid，soluble protein content and total nitrogen and phosphorus mineral content，transpiration rate，stoma conductance and net photosynthetic rate，soil conductivity，alkali hydrolyzable nitrogen and available phosphorus content and urease and sucrase activities of T5 treatment group were the highest；③ Compared with single application of organic fertilizer，in the mixed application of organic fertilizer and water-soluble fertilizer，the height，crown width，branch length，leaf width were significantly increased by 24.8%，19.9%，26.2%，24.7%，respectively，the soluble sugar，total nitrogen content of the leaves significantly increased by 64.8%，25.3%，respectively，soil nutrient content and urease activity also increased but did not reach a significant level.Comprehensive analysis results can be obtained as follows:Single or mixed application of water-soluble fertilizers，organic fertilizers，and controlled-release fertilizers can promote the growth of H.macrophylla‘Hanatemari’，promote plant photosynthesis and the accumulation and conversion of nutrients，and improve soil fertility.Among them，the combined application of controlled-release fertilizer and water-soluble fertilizer has the best growth-promoting effect and soil improvement effect of H.macrophylla‘Hanatemari’.Mixed fertilization，as a new trend of fertilizer application at present，can better promote the growth of Hydrangea than single fertilization.