In order to explore the effects of different densities，base fertilizer(organic fertilizer)，top dressing (compound fertilizer) and seedling configuration on the yield，photosynthetic characteristics and quality of leafy sweet potato，the leafy sweet potato variety ‘Wancaishu 19’ was used as the experimental material，four factors and three levels orthogonal experimental design was adopted with 3 repetition，and the changes in the yield，photosynthetic characteristics，quality and other factors of leaf-vegetable sweet potatoes were analyzed in three harvest periods，and the determinants and optimal combinations were clarified to provide theoretical reference for high-yield and high-quality cultivation techniques of leafy sweet potato.The results showed that the yield was mainly determined by planting density，and the yield increased with the increase of density and topdressing，indicating that the yield of leafy sweet potato could be improved by appropriately increasing density and topdressing；The theoretical optimal combination for yield is D3S2B2T3，that is，the density is 222000 plants·hm-2，the seedlings are two-stage seedlings，and it is easier to obtain high yield with the amount of base fertilizer 4500 kg ·hm-2 and top dressing 1800 kg ·hm-2.Chlorophyll SPAD value，functional leaf area，net photosynthetic rate，stomatal conductance，intercellular CO₂ concentration and transpiration rate are mainly determined by planting density，base fertilizer dosage and top dressing dosage，and have a trend of decreasing with the increase of planting density and increasing with the increase of base fertilizer and top dressing dosage.The differences among treatments are very significant，and the effects of seedlings are not significant；The theoretical optimal combination is D1S1B3T3，that is，the density is 133000 plants ·hm-2，the seedlings are shoot tip seedlings，the amount of base fertilizer is 9000 kg·hm-2，the amount of topdressing is 1800 kg ·hm-2，and the photosynthetic characteristics index is higher.The quality is mainly determined by the planting density，the amount of base fertilizer and the amount of topdressing.The amount of base fertilizer is the main determinant.The contents of total sugar，crude protein，vitamin C and dry matter increase with the increase of the amount of organic fertilizer.The change law of cellulose and nitrate is opposite，and the difference between treatments is very significant，and the quality difference between different seedlings is not significant.The theoretical optimal combination is D1S3B3T3，that is，the density is 133000 plants ·hm-2，the seedlings are three section seedlings，the amount of base fertilizer is 9000 kg·hm-2，the amount of topdressing is 1800 kg·hm-2，and the quality is the highest.