To enhance the efficiency of antibiotics-degrading bacteria and reduce the risk of the spread of antibiotics resistance genes (ARGs) that may be caused by strains during the composting process，a mesophilic ciprofloxacin-degrading strain WXX-3 was screened from the aerobic composting strips，and a simulated composting experiment was conducted to explore the effects of strain WXX-3 on the ciprofloxacin degradation and ARGs abundance.The strain was added to pig manure at 0.05% of the inoculum，piled up 8 days for its propagation at 20～30 ℃，and then some conditioner such as wood chips was added to compose for 30 days as conventional compost，the removal rate of ciprofloxacin reached 82.9%，which was 27.6 percentage points higher than the treatment without WXX-3.The high temperature of compost inhibited the growth of WXX-3，after composting，the WXX-3 was not detected.During the composting，the abundance of fluoroquinolone resistance genes and intI1 genes were reduced to different degrees，mexA and qnrA were removed completely，and the contents of qepA，acrB-0 and intI1 were removed 17.9%，43.8% and 71.7%，respectively，which significantly higher than the treatment without WXX-3.The above results indicated that the strain WXX-3 can effectively remove ciprofloxacin，and the supporting composting measures can exert the degradation potential of this strain and reduce the risk of ARGs contamination.