Aiming at a series of problems such as soil hardening，acidification and fertilizer supply capacity decline caused by continuous tobacco planting and excessive application of chemical fertilizer in China，a phosphorus solubilizing bacteria with excellent phosphorus solubilizing effect was screened and bred from the rhizosphere soil near a coal gangue open storage site in Guizhou province，and its number was GZ-11. The strain was identified as Bacillus toyonensis by physiological and biochemical tests and molecular biology. GZ-11 was used to dissociate coal gangue to prepare coal gangue microbial fertilizer. On the basis of coal gangue microbial fertilizer，different proportions of nitrogen，phosphorus and potassium were mixed to prepare the first kind of coal gangue tobacco compound fertilizer(A) and the second kind of coal gangue tobacco compound fertilizer(B). The effects of two kinds of coal gangue tobacco compound fertilizers on tobacco growth and quality were studied by field experiments with tobacco specific fertilizers (CK) as contrast. The results showed that:(1) The content of available phosphorus，alkali-hydrolyzable nitrogen and available potassium in coal gangue after GZ-11 dissociation were 132.40，720.63 and 815.60 mg/kg，respectively，which were 14.38，5.99 and 6.01 times of the original gangue. (2) There was no significant difference in stem circumference and maximum leaf area among the three treatments at the capping stage；in the performance of tobacco plant height，A treatment was significantly higher than CK treatment. (3) Compared with CK，the chemical components (nicotine，total sugar，reducing sugar，total nitrogen，potassium，chlorine content) of tobacco leaves under A and B treatments were closer to those of high-quality tobacco. The above results showed that the two kinds of coal gangue tobacco compound fertilizers had little difference in promoting tobacco agronomic properties compared with tobacco specific fertilizers，and were superior to tobacco specific fertilizers in improving tobacco quality，which could promote the green development of tobacco agriculture.