The effects of Lycium ruthenicum Murr. on improving the saline-alkali land in extreme arid area and the interaction between salt and soil organic matter were discussed. Continuous field monitoring was conducted to compare the survival rate of Lycium ruthenicum Murr. plants under moderate saline soil(5-10 g/kg)，severe saline soil(10-22 g/kg)and saline soil(>22 g/kg)，and the effects of three years of cultivation on contents of Na+，Cl-，SO42-，organic matter and alkali-hydrolyzable nitrogen in 0-20，20-40，40-60 soil layers and fruit yield. The results showed that there was a quadratic function between the total salt content in soil and the survival rate of Lycium ruthenicum Murr.，and the total salt content being greater than 7.97 % could kill Lycium ruthenicum Murr.. In addition，after the cultivation of Lycium ruthenicum Murr.，the contents of Na+，Cl- and SO42- of the three saline soil 20-40 cm soil layers decreased significantly，while the contents of salt ions in the other soil layers did not decrease significantly. The content of alkali-hydrolyzable nitrogen in saline soil increased significantly，while the organic matter and alkali-hydrolyzable nitrogen in other types of saline soil decreased significantly. The decrease rate of soil total salt was negatively correlated with the increase of soil organic matter. The restored saline soil was conducice to a significant increase in the yield of Lycium ruthenicum Murr.. In conclusion，the yield increase of Lycium ruthenicum Murr. reduced contents of Na+，Cl-and SO42- in the moderate to severe saline soil，and consumed more nutrients in 20-40 cm soil layer.