In order to clarify the appropriate fertilization application rate and remained leaves and improve the comprehensive benefit of tobaccoproduction，the study of fertilization application rate and remained leaves on theagronomy，economic and quality properties of tobacco leaves wereanalyzed by interpolation method. The results showedthat，as the fertilization application rate increased from 450 kg·hm-2 to 600 kg·hm-2，the growth rate of flue-cured tobacco was increased significantly. The total score of theyield，the averageprice，and the coordination evaluation of the main chemical composition of the middle and upper tobacco leaves were gradually improved. As the remained leaves increased from 16 to 20slices perstrain，the difference between the maximum leaf area and the inverted trefoil area gradually increased. The shapes of plants varied from“inverted tower shape”to“cylindrical shape”to“tower shape”.Meanwhile，the yield and output value were significantly increased by 20.8% and 18.8% and top-grade rate and average price were reduced by 7.6% and1.5%， respectively. This brings about the increasing net income of tobacco planted. The total score of the coordination evaluation in the main chemical composition in the middle and upper tobacco leaves showed a law of increasing first and then decreasing.Therefore，in the process of tobaccoproduction，it was suggested to increase the nutrient supply rate moderately andremainedleaves，which wasnot only conducive to improve the overall quality of tobaccoleaves，but also could bring about a high net income of flue-cured tobacco planted.