This study comparatively analyzed the rhizosphere microbiome of watermelon in Beijing. The results showed that the microbial composition was affected largely by geographicareas，and phosphorus and potassium were two major factors in microbiome shaping. The bacterial community network in the healthy rhizosphere was more stable and had more hubs than that of diseased plants. Ninth bacterial genera from 5 phyla were defined directly related to Fusarium，in which Bacillus and Pseudomonas were positively correlated with fusarium wilt. Through a comprehensive study on the difference of rhizosphere bacteria composition between healthy and Fusarium infected watermelon plants by ampliconsequencing，we constructed a correlation network and identified the promising bacterial community in preventing bacterial blight. These findings paved the way for early detection and control of watermelon fusarium wilt in the Beijing area.