Drought is one of the main factors restricting wheat productivity and it is important to explore the effects of manganese on wheat leaf senescence under different soil water conditions. In an outdoorpotexperiment，three levels of soil watertreatments(CK: normalwater，which was 70%-75% of the maximum field watercapacity，MS: moderate watershortage，which was 50%-55% of the maximum field watercapacity，SS: severe watershortage，which was 40%-45% of the maximum field watercapacity)and five concentrations of MnSO 4solution(0%，0.2%，0.5%，1.0%，2.0%)spraying on wheat leaves during booting and flowering period were set up. Theactivities of superoxide dismutase(SOD)，peroxidase(POD)andmalondialdehyde(MDA)in wheat leaves were determined. The fitting results showed that the lowest MDA content in wheat leaves after two spraying treatments was 3.19 and 4.04 g/L under CK treatmentrespectively，which was still lower under MS and SS treatments and the MDA content in wheat leaves was significantly reduced. When POD activity reached itsmaximum，the corresponding manganese concentrations were 5.13 and 4.30 g/L under MS treatmentrespectively，and the corresponding manganese concentrations were significantly different under the CK and SS treatment. When SOD activity reached its maximum after twosprays，the corresponding manganese concentration was above 10 g/L and SOD activity was increased under each treatment. The application of manganese fertilizer reduced the MDA content of wheat leaves and increased the activities of SOD andPOD，which could delay the senescence of wheat leaves under different soil waterconditions，but the optimal concentration was different.