The effects of different irrigation amounts and combined application of organic and inorganic fertilizers on winter wheat growth and water use efficiency were explored to provide reference for scientific fertilization management of winter wheat.Taking the winter wheat‘ Xiaoyan 22’ in Guanzhong area as the research object，through field experiments，the organic fertilizer and inorganic fertilizer were applied in different proportions(F1，100% inorganic fertilizer；F2，24% organic fertilizer+76% inorganic fertilizer；F3，48% organic fertilizer+52% inorganic fertilizer) according to the principle of equal nitrogen，and 6 irrigation and fertilization combinations(W1F1，W1F2，W1F3，W2F1，W2F2 and W2F3)were designed in combination with two levels of irrigation(full irrigation W1 and deficit irrigation W2).By measuring the growth indicator(plant height and leaf area index) of winter wheat，soil volume moisture content in 0-200 cm soil layer(with a depth interval of 20 cm)，wheat yield and its components(dry matter weight，panicle length，effective ear number，1000 grain mass and grain yield)，the effects of irrigation amount and organic and inorganic fertilizers on winter wheat growth and water use efficiency(WUE) were analyzed.The results showed that:(1) Under the condition of full irrigation(W1)，the plant height of F2 and F3 treatments increased by 3.4%-21.2% and 0.8%-15.9%，the leaf area index increased by 5.7%-18.5% and 16.8%-47.4%，the dry matter weight increased by 12.1%-26.1% and 21.1%-36.0%，the panicle length increased by 12.5% and 14.5%，the effective ear number increased by 6.6% and 9.3%，the 1000-grain mass increased by 18.3% and 24.4%，the grain yield increased by 14.8% and 28.6%，and the WUE increased by 14.6% and 27.5%，respectively. Under the condition of deficit irrigation(W2)，compared with F1 treatment，F2 and F3 treatment increased plant height by 8.5%-16.2% and 0.5%-10.6%，leaf area index by 4.9%-20.7% and 17.0%-50.0%，dry matter weight by 7.7%-25.7% and 15.0%-34.6%，panicle length by 12.3% and 18.5%，effective ear number by 7.4% and 18.0%，1000-grain mass by 15.3% and 25.1%，grain yield by 13.1% and 31.8%，WUE by 21.4% and 35.2%，respectively.Combined application of organic and inorganic fertilizers improved the soil volume moisture content under the same irrigation level.(2)W2F2 treatment was the most effective on the growth of plantheight of winter wheat，reaching the maximum value at the filling stage，being 10.4% higher than W1F1 treatment. W2F3 treatment had the greatest impact on the leaf area index，dry matter weight，panicle length，effective ear number and 1000-grain mass of winter wheat，and it was 23.6%，39.0%，20.3%，18.4% and 33.1% higher than W1F1 treatment at the maturity stage，respectively.(3) The effect of W2F3 treatment on the grain yield and WUE of winter wheat was the most significant. Its grain yield was 35.5%，18.0%，5.3%，31.8% and 16.6% higher than that of W1F1，W1F2，W1F3，W2F1 and W2F2 treatments，respectively；Compared with W1F1，W1F2，W1F3，W2F1 and W2F2，WUE of W2F3 treatment increased by 52.6%，33.2%，19.7%，35.2% and 21.4%，respectively. The combination of deficit irrigation and 48% organic fertilizer+52% inorganic fertilizer had the highest yield and WUE of winter wheat. The irrigation and fertilization management plan laid the foundation for scientific fertilization management of winter wheat in the Guanzhong plain and similar environmental areas.