In order to explore the fertilization effect of different organic materials，guide the rational utilization of organic materials，and promote high and stable crop yields，the combined application test of organic materials and chemical fertilizers was carried out. And five treatments were set up with corn as the test crop，namely single application of chemical fertilizer(CK)，sheep manure+chemical fertilizer(AF)，cassava residue+chemical fertilizer(PF)，woody peat+chemical fertilizer(MF)，monosodium glutamate waste slurry+chemical fertilizer(IF)，and the effects of different treatments of organic materials and chemical fertilizer dosage on soil physical and chemical properties and maize nutrient uptake and yield were studied. The results showed that compared with CK，the soil organic matter content of AF，PF，MF and IF treatment increased by 8.96%，18.60%，7.93% and 24.67%，respectively，and the contents of alkaline hydrolyzable nitrogen，available phosphorus and available potassium were also increased. The soil conductivity was reduced by MF treatment，and soil pH was reduced by other treatments except AF treatment. Among them，the IF treatment had the highest content of soil organic matter，PF treatment soil with the highest content of alkaline hydrolyzable nitrogen and available potassium，and AF treatment soil with the highest available phosphorus content. The application of organic materials increased the nutrient content and accumulation of maize plants，and increased the yield of maize. Among them，the nitrogen and potassium contents and accumulation of maize stems and leaves treated with IF treatment were the highest ，and the potassium accumulation of grain was also the highest. AF treatment maize had the highest phosphorus content and accumulation in stems and leaves，and the highest potassium content in grains. PF treatment maize grains had the highest phosphorus content and accumulation. The application of organic materials increased the yield and yield composition factors of maize，among which MF treatment maize had the highest number of grains per ear，PF treatment maize ear weights were the highest，and IF treatment maize had the highest 100-grain weight. Compared with CK，the yields of maize treated with AF，PF，MF and IF treatment increased by 9.97%，16.22%，7.65% and 17.03%，respectively，among which the yield increase effect of IF treatment was the best. It could be seen that the combined application of different organic materials and chemical fertilizers could improve soil physical and chemical properties，promote the absorption and utilization of corn nutrients，and increase maize yield，but the effects of different organic materials were different.