Jinggang pomelo is one of the three major brands in the fruit industry of Jiangxi province. Soil acidification caused by improper fertilizer application is one of the important feature of soil degradation in pomelo orchards and a key factor restricting the yield and quality of honey pomelo fruits. 6-year-old Jinsha pomelo trees in Ji’an，Jiangxi were selected，and field experiment was conducted from 2020 to 2022 including two treatments：farmers’fertilization practice and acid regulation and fertilization techniques （substituting 30% chemical fertilizer with organic fertilizer + lime + silicon-calcium-potassium-magnesium fertilize + green manure intercropping）to investigate the effects of acid regulation and fertilization techniques on soil，fruit yield and quality. The results showed that compared with farmers’fertilization practice，the acid regulation and fertilization techniques increased the soil pH by 0.93 units over 3 years（P＜0.05），and the organic matter content by 19.17%（P＜0.05）. The contents of alkaline nitrogen， available phosphorus，available potassium，exchangeable magnesium，and exchangeable calcium in the soil were significantly increased. The soil quality index（SQI）was significantly improved by 0.25（P＜0.05），and the nitrogen，potassium， magnesium，and calcium contents in the pomelo leaves were also significantly increased. Moreover，acid regulation and fertilization techniques significantly raised the yield by 25.99%（P＜0.05），and the vitamin C content and sugar-acid ratio of the fruits were elevated by 5.85% and 23.60%，respectively（P＜0.05），while the titratable acidity content significantly decreased. In addition， acid regulation and fertilization techniques enhanced the annual output value of pomelo orchard by RMB 34100 per hectare and the average economic benefits by RMB 22800 per hectare over 3 years. In summary，the acid regulation and fertilization techniques could reduce soil acidity in red soil pomelo orchards increase soil nutrient content and nutrient absorption in leaves，improve tree nutrition，enhance fruit yield and quality，enhance the economic benefits of orchards，and provide an effective measure to improve soil quality and enhance the quality of Jinggang pomelo orchards.