In order to study the fertilizer effect of flue-cured tobacco under different fertilizer dosage and determine the appropriate fertilizerapplication dosage，a field experiment wascarried out in Longyancity，Fujianprovince，using Yunyan87，the local maincultivar，as the material. The effects of combined applicationof nitrogen(N)，phosphorus(P)andpotassium(K)fertilizers on nutrientuptake，relativeyield，nutrient factorslimiting yield，economic characteristics and fertilizer utilization rate of flue-cured tobacco were studied. The results showed that the nutrient accumulationofN，P and K was K > N > P during the growth period of flue-curedtobacco，and the nutrient accumulation mainly concentrated in the flourishing period. The yield and economic properties of flue-cured tobacco in Longyan tobacconic area were reduced by lack of nutrients.The effects of lack ofnitrogen，phosphorus and potassium on yield and economic properties of flue-cured tobacco were asfollows:lack of nitrogen>lack of phosphorus>lack of potassium. In different nitrogen applicationtreatments，N3treatment(N:135 kg/hm²，P2O5:105 kg/hm²，K2O:375 kg/hm²)had the best indicators. The yield was 2053.17 kg/hm²， the proportion of high-grade tobacco was79.64%，the proportion of medium-grade tobacco was95.64%，the output value was 61850.36 Yuan/hm²，the average price was30.12Yuan/kg，the nitrogen utilization rate was31.27%，the agronomic utilization rate was11.28 kg/kg，and the partial productivity was 15.21 kg/kg. Nitrogen application and tobacco yield were fitted with the fertilizer effectequation，which was y=511.488+1.3614x+0.116x2-0.0004x3(R2=0.9812). Consideringtobaccoyield，fertilizer utilization rateand economicbenefit，the recommended nitrogen application rate in Longyan area is 135.0-177.2 kg/hm².