In thispaper，the effects of urea with different levels of nitrification inhibitor3，4-dimethylpyrazole phosphate(DMPP)(1%，3%，and 5% of nitrogenapplied)on soilcadmium(Cd)morphology， Panax notoginseng growth and plant Cd enrichment and translocation were studiedby exogenously addingCd(5 mg·kg -1)in apotexperiment，in order to clarify the mechanism of its inhibition and control of Cd accumulation in P. notoginseng.Single application of urearesulted in 0.70 decrease in soilpH，while urea combined with DMPP increased soil pH by 1.05 to1.24，and the soil NH4+-N content increased with the increase of the DMPPapplication.Single application of urea increased the content andproportion of soil exchangeableCd，resulting in higher Cd activity in thesoil，while the application of DMPP promoted thetransformation of soil Cd from the highly active exchangeable state to the less active residuestate.The Cd contents ofstems， leaves and plants in P. notoginseng were the highest under CKtreatment，while the Cd content in P. notoginseng roots was the highest under single application ofurea，indicating that nitrogen application reduced the transport of Cd from roots toshoots.The application of ureacombined with DMPP increased the leaflength，leafwidth，plant height and biomass of P. notoginseng，and drastically reduced the Cd contents inroots，stems，and leaves.The comprehensive analysis revealed that urea combined with 1% DMPP had the besteffect.Therefore，urea combined with DMPP could increase the pH ofrhizospheresoil，reduce soil Cdactivity，thus inhibiting the accumulation of Cd in P. notoginseng.