To investigate the effects of manganese(Mn)on the growth and development of wheat and the cadmium(Cd)absorption and transport in northern calcareous Cd-contaminated soil，a pot experiment was carried out to examine the effects of Mn fertilizer addition(100 mg/kg)on Cd and Mn availability in soil and Cd and Mn uptake and translocation in wheat. The results indicated that the application of Mn resulted in a decrease in soil pH and soil available Cd，while simultaneously increasing soil available Mn. Compared with Cd，Mn application increased the biomass of wheat straw，glume，and grain，and alleviated Cd toxicity in wheat. Mn application significantly reduced Cd concentration in the wheat root，straw，glume and grain by 15.25%，10.64%，13.02% and 22.60%，respectively，when compared to Cd treatment. Compared to Cd treatment，Mn concentration in wheat tissues increased by 15.69%-31.22%. Meanwhile，the results of correlation analysis and fitting equation showed that wheat root Mn concentration was negatively correlated with shoot Cd concentration and root-to-shoot Cd transfer coefficient，and wheat grain Cd concentration was negatively correlated with Mn，Fe and Zn concentrations of root and grain. The comprehensive analysis showed that Mn fertilizer application increased available Mn content in soil，and promoted Mn absorption and the bioavailability of Fe and Zn elements in roots，thus inhibiting Cd absorption in roots and reducing the Cd transfer from roots to shoots. In calcareous Cd-contaminated soil，more effective measures or agronomic techniques are needed to further reduce wheat grain Cd accumulation.