The optimum nitrogen application rate and fertilizer application method applicable to single-season direct-seeded rice Nangeng 46 were explored，with a view to providing technical solutions for the light simplified production of rice and the efficient utilization of nutrient resources in Chongming district，Shanghai. A field experiment was conducted from June to November，2022. Five treatments were conducted:no nitrogen application，farmer’s conventional fertilization，one-time fertilization，one follow-up application at tillering stage，and two follow-up applications at tillering+spike stage. The impacts of different nitrogen applications and transport methods on the growth dynamics，yield，nitrogen uptake and utilization，rice quality，and economic benefits of rice were analyze. A side-depth single fertilization technique was adopted for the main rice variety (Nangeng 46) in Chongming，Shanghai. The nitrogen fertilization mode of applying special slow-release fertilizers and keeping the pure nitrogen nutrient input at 225 kg/hm² was able to obtain the best yield and rice quality，reducing nitrogen by 27.2%，compared with the conventional fertilization treatment by local farmers，and at the same time reducing the number of 2-3 times of fertilizer application at the late stage of the rice crop and lowering the cost by 14.0%，with a yield/input ratio of 1.94. This fertilization mode had the highest nitrogen utilization rate of 47.5%，which increased by 51.0%，compared with the conventional treatment of local farmers. The one-time side-depth fertilization technique with new fertilizer application could achieve optimal rice yield，rice quality and economic benefits at a pure N input of 225 kg/hm².