A bacterial strain S8797 was isolated from frequent occurrence sites of tobacco bacterial wilt and black shank diseases in Zunyi. This strain exhibited significant disease control and growth-promoting capabilities. It effectively antagonized 12 plant pathogens including Ralstonia solanacearum and Phytophthora nicotianae. Moreover，it demonstrated abilities in dissolving inorganic phosphorus，potassium solubilization，cellulase enzyme production，and NH₃ production. Through analysis utilizing 16S rDNA，multigene sequence phylogenetics，and average nucleotide identity，strain S8797 was identified as Pantoea dispersa. The genome size of S8797 was determined to be 4.86 Mb without any plasmids，with a GC content of 57.4%. It comprises 4399 coding genes and 81 non-coding genes. Furthermore，the prediction using antiSMASH revealed the presence of 6 potential secondary metabolite biosynthetic gene clusters. Biological assays demonstrated that strain S8797 effectively controlled tobacco bacterial wilt，achieving a control efficacy of 55.0% in pot experiments. Tobacco plants treated with S8797 suspension exhibited vigorous growth，with significantly greater height compared to the control. These results highlighted the broad-spectrum antagonistic capabilities of Pantoea dispersa S8797 against plant pathogens，indicating its potential in disease control and growth promotion in tobacco，meanwhile laid the groundwork for the development of Pantoea-based biocontrol agents and microbial fertilizers.