The effects of different types of iron(Fe)fertilizers[EDTA-Fe，nano-sized iron oxide(FeNPs)，FeSO4]and application methods(soil application，foliar spraying)on Cadmium(Cd)accumulation in wheat were studied by pot experiment with winter wheat ‘Bainong 207’ as the test material under Cd contaminated soils(4 mg/kg Cd).The results showed that soil application of different types of Fe fertilizers(EDTA-Fe，FeNPs，FeSO4)reduced the soil available Cd content by 29.46%，20.00% and 24.83%，respectively.Both soil application and foliar spraying of FeSO4 significantly increased the biomass of wheat grains，whereas soil application of EDTA-Fe significantly reduced the biomass of each part of wheat due to the toxic effect at seedling stage.The two types of Fe fertilizer application methods showed different degrees of reduction in Cd content in all tissues of wheat，which mainly reduced the uptake of Cd by the root system.Among them，soil application of different types of Fe fertilizers reduced Cd content in wheat roots by 10.75%-27.50%，and foliar spraying reduced it by 11.94%-21.28%. Spraying EDTA-Fe and FeNPs were more effective on reducing Cd content in wheat grains.In addition，the contents of Fe，Cu and Zn in different tissues of wheat varied with different Fe sources and application methods.In conclusion，soil available Cd content，type of Fe fertilizer and application method all affected the accumulation of Cd in wheat plants.Reasonable selection of Fe fertilizer type and appropriate application method could effectively reduce the Cd content of wheat grains in Cd-contaminated soils.