The fertilization of chrysanthemum planting in Anhui province is highly arbitrary and lacks unified standards. By exploring reasonable fertilization methods for chrysanthemums，it could provide data support for high-quality and high-yield chrysanthemums. A fertilizer reduction ratio experiment was set up:3000 kg/hm² of bioorganic fertilizer and 900 kg/hm² of compound fertilizer(18-18-18)；Bioorganic fertilizer 3000 kg/hm²+formula fertilizer(18-7-20)900 kg/hm²；Bioorganic fertilizer 3000 kg/hm²+formula fertilizer(18-7-20)720 kg/hm²；Bioorganic fertilizer 3000 kg/hm²+formula fertilizer(18-7-20)540 kg/hm²；CK:Bioorganic fertilizer 3000 kg/hm². And an experiment on base fertilizer and topdressing ratio was conducted:8-2-0，2-6-2，4-4-2，8-0-2. By comparing and analyzing the nutrient accumulation，growth status，and medicinal component content of chrysanthemum plants，the effects of fertilization measures on chrysanthemum growth，quality，and yield were explored. The results showed that the optimized fertilizer ratio(reducing phosphorus and increasing potassium)increased the content of chlorogenic acid，luteolin，and 3，5-O-dicaffeoyl quinic acid by 34.09%，3.76% and 28.44%，respectively，compared to conventional fertilization treatment，and the yield significantly increased by 21.79%. The treatment of reducing fertilizer application by 20%，compared to conventional treatment，resulted in an increase in the diameter of chrysanthemum main stem，number of flowers per plant，and weight of 100 fresh flowers. The content of chlorogenic acid，luteolin，and 3，5-O-dicaffeoyl quinic acid increased，and the yield increased by 36.61%，25.46% and 174.18%，respectively，compared to conventional fertilization treatment，40% reduction of fertilizer application treatment，and CK treatment. Chrysanthemums with the treatment of 4-4-2 of base fertilizer and topdressing ratio exhibited better growth，with higher content of chlorogenic acid，luteolin，and 3，5-O-dicaffeoyl quinic acid，and the yield increased by 12.76%，3.33% and 10.81%，respectively，compared to other treatments. In summary，it was concluded that the bioorganic fertilizer 3000 kg/hm²+formula fertilizer(18-7-20)720 kg/hm²，applied in a ratio of 4-4-2 during the early stage of chrysanthemum colonization，flower bud differentiation，and bud emergence，could promote the absorption and utilization of a large number of elements by chrysanthemum plants，improve the agronomic characteristics of chrysanthemums，and enhance their quality and yield.