Global warming，water resources and soil salinity changes caused by climate change have brought great challenges to agricultural production and seriously threatened food security. In addition，the overuse of production inputs such as fertilizers and irrigation water in agriculture has led to the degradation of land and water resources，further exacerbating climate change and ultimately negatively affecting agricultural production. In view of the importance of agricultural production to food security，agricultural intensification measures are needed to increase food productivity while protecting the environment to ensure the stability and sustainability of food supply. As a product in EU countries play a role in promoting plant growth，enhancing stress resistance and improving product quality，bioactive substances are one of the effective strategies to strengthen sustainable agricultural practices. The progress of the application of humic acid，alginate，amino acids and other bioactive substances as fertilizer synergists in synergistic fertilizers at home and abroad was reviewed. The number and types of bioactive substances applied to domestic registered products were described. The application prospects of bioactive substances in high-quality development in the future were prospected.