The area and degree of soil acidification are increasing in southern Henan province，threatening food production and the ecological environment. This study conducted a cultivated experiment using in-situ acidic farmland soils to explore the impact of different remediation materials on soil quality in southern Henan. Two inorganic materials(A:lime，B:calcium-magnesium phosphate fertilizer)and three organic materials(C:biochar，D:potassium humate，and E:carbon adsorption polyglutamic acid)were separately and randomly combined for application. Soil pH，electrical conductivity，soil nutrients，aggregates and enzyme activity were measured，and the minimum data set analysis was used to evaluate the soil quality after amendment. The results showed that the inorganic amendment treatments A and AB showed the most effective in raising soil pH，while the organic amendment treatments significantly improved soil quality. The combined application of organic carbon and nitrogen materials(treatment CE)had the best effect on improving soil quality，followed by the mixture of organic and inorganic materials，with inorganic materials showing the smallest improvement. Biochar applied independently or combined with other materials(treatments C，BC，AC，CD，CE，ACD，ACE，and CDE)significantly increased soil pH，electrical conductivity，available potassium content，and the proportion of micro-aggregates；lime applied independently or combined with other materials(treatments AB，AC，AD，AE，ABD，and ABE)significantly increased soil total nitrogen；calcium-magnesium phosphate fertilizer applied independently or combined with other materials(treatments B，AB，BC，BD，BE，ABC，and ABD)significantly increased soil available phosphorus；treatment CE significantly increased soil sucrase and urease activities. Treatments CE，C，BCDE，ACD，ACE，ABCD，ABC，CD and ABCDE increased soil quality composite index(SQI)by 31%~52%. The SQI was significantly positively correlated with soil pH，electrical conductivity，available potassium，and soil micro-aggregates. In summary，inorganic materials significantly mitigated soil acidification，while organic materials predominantly enhanced soil quality；the combined application of multiple materials could improve soil structure，increase soil salinity，alleviate soil acidification，enhance soil enzyme activity and nutrient availability，thereby improving soil quality.