Using ‘QinCui’ apple as the test material，a five-factor [nitrogen(N), phosphorus(P2O5)，potassium(K2O)，calcium(CaO)and magnesium(MgO)]four-level orthogonal experiment L16(45)was conducted under drip-irrigation. The four application levels were set as multiples(0，0.5，1.0，and 1.5 times)of the baseline fertilization rate for each fertilizer, with conventional field fertilization serving as the control(CK)，totaling 17 treatments. This study systematically investigated the effects of different fertilization combinations on apple yield and quality. The aim was to provide theoretical and technical references for fertilization in drip-irrigated apple cultivation. A comprehensive evaluation of yield and fruit quality under various fertilization treatments was conducted using variance analysis and principal component analysis(PCA). The optimal fertilization ratios of N，P2O5，K2O，CaO and MgO were determined through range analysis. The results showed that different fertilization treatments significantly improved the yield and quality of ‘QinCui’ apples. The highest yield was observed in T13 (N 360.00 kg/hm²，K2O 360.00 kg/hm²，CaO 49.00 kg/hm²，MgO 15.00 kg/hm²)treatment，reaching 70.36 t/hm²，followed by T7 (N 120.00 kg/hm²，P2O5 195.00 kg/hm²，K2O 360.00 kg/hm²，MgO 7.50 kg/hm²)and T6 (N 120.00 kg/hm²，P2O5 97.50 kg/hm²，CaO 147.00 kg/hm²，MgO 15.00 kg/hm²)treatments，with yield increases of 24.69 and 20.42 t/hm²，respectively，compared to CK. PCA results indicated that the T2 (P2O5 97.50 kg/hm²，K2O 120.00 kg/hm²，CaO 49.00 kg/hm²，MgO 7.50 kg/hm²)treatment significantly enhanced the reducing sugar content(48.87 mg/g)and peeled firmness(4.16 kg/cm2). T5 (N 120.00 kg/hm²，K2O 120.00 kg/hm²，CaO 98.00 kg/hm²，MgO 22.50 kg/hm²)treatment significantly improved titratable acid content(0.22%)and yield(55.21 t/hm²). T6 treatment showed strong effects on increasing soluble sugar content(14.84%)，reducing sugar content(51.34 mg/100 g)，and vitamin C(Vc)content(8.54 mg/100 g). T7 treatment significantly improved total anthocyanin content(0.13 mg/g)and single fruit weight(255.27 g). T15 (N 360.00 kg/hm²，P2O5 195.00 kg/hm²，K2O 120.00 kg/hm²，CaO 147.00 kg/hm²)demonstrated significant effects on increasing Vc content(5.14 mg/100 g)and total protein content(131.41 mg/g). Among the treatments，the comprehensive evaluation of fruit yield and quality was the highest in T6 treatment，indicating that T6 treatment had the best overall effect on increasing yield and improving fruit quality among all fertilization combinations.